PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery.

Jing Li,Xue-Qi Liang,Yun-Feng Cui,Yu-Yang Fu,Zi-Yue Ma,Ying-Tao Cui, Xian-Hui Dong,Hai-Jun Huang,Ting-Ting Tong, Ya-Mei Zhu,Ya-Dong Xue, Yong-Zhen Wang,Tao Ban,Rong Huo

PeerJ（2023）

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摘要

PFI-3 blunted PE and high K-induced vasoconstriction independent of endothelium on rat mesenteric artery. The vasodilatory effect of PFI-3 may be attributed to its inhibition of VDCCs and receptor-operated calcium channels (ROCCs) on vascular smooth muscle cells (VSMCs).

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关键词

PFI-3, Vasoconstriction, Vasodilation, Calcium channels

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