Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice.

Jing Lu,Feng Liang,Ping Bai, Chenghao Liu,Miao Xu, Zhengwang Sun,Wenjie Tian,Yuanlin Dong,Yiying Zhang,Qimin Quan,Ashok Khatri,Yuan Shen,Edward Marcantonio,Gregory Crosby,Deborah J Culley,Changning Wang,Guang Yang,Zhongcong Xie

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

Acute increases in blood tau-PT217 may contribute to brain dysfunction and postoperative delirium. Targeting B cells or mitochondrial function may have therapeutic potential for preventing or treating these conditions.

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关键词

anesthesia, delirium, phosphorylated tau at threonine 217, surgery, tau, tau phosphorylation

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