Activation of sphingomyelin phosphodiesterase 3 in liver regeneration impedes the progression of colorectal cancer liver metastasis via exosome-bound intercellular transfer of ceramides.
Cellular and molecular gastroenterology and hepatology(2023)
Abstract
SMPD3-produced exosomal CER constitutes a critical anti-CRLM mechanism in LR to impede CRLM, offering the promise of utilizing CER as a therapeutic agent to prevent the recurrence of CRLM after PH.
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Key words
sphingomyelin phosphodiesterase,liver regeneration impedes,intercellular transfer,colorectal cancer,exosome-bound
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