Necrostatin-1 attenuates delayed paraplegia after transient spinal cord ischemia in rabbits by inhibiting the upregulation of receptor-interacting protein kinase 1 and 3.

Takuya Nishijima,Satoshi Fujita,Takeaki Harada, Hikaru Uchiyama, Kensaku Matsuda, Hiroshi Mitsuo,Tomoki Ushijima,Meikun Kan-O, Gen Shionohara,Satoshi Kimura,Yasuhisa Oishi,Hiromichi Sonoda,Akira Shiose

Annals of vascular surgery（2023）

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摘要

These data suggest that Nec-1 reduces delayed motor neuron death and attenuates delayed paraplegia after transient spinal cord ischemia in rabbits by selectively inhibiting necroptosis of motor neurons, with minimal effect on their apoptosis.

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关键词

transient spinal cord ischemia,protein kinase,receptor-interacting

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