Urinary metabolomic biomarker candidates for skeletal muscle wasting in patients with rheumatoid arthritis.

Marianne S Oliveira,Rafaela C E Santo,Jordana M S Silva,Paulo V G Alabarse,Claiton V Brenol,Steve P Young,Ricardo M Xavier

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

Isobutyric acid, oxoisovalerate, and dimethylglycine from urine samples were associated with low skeletal muscle mass in patients with RA. These findings suggest that this group of metabolites may be further tested as biomarkers for identification of skeletal muscle wasting.

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关键词

Nuclear magnetic resonance, Loss of muscle mass, Rheumatoid arthritis, Metabolomics, Cachexia, Sarcopenia

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