Sensitive measurement of clinically relevant factor VIII levels in thrombin generation assays requires presence of factor XIa.

Tom William van de Berg,Erik A M Beckers,Floor C J I Heubel-Moenen,Yvonne M C Henskens,Stella Thomassen,Tilman Mathias Hackeng

Thrombosis and haemostasis（2023）

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摘要

We propose a critical optimization for the setup of the thrombin generation assay for measurements in severe HA plasma. The dual TF/FXIa TGA shows increased sensitivity, especially in lower FVIII ranges, which allows for better individual characterization at baseline, predictions of interventions and follow-up.

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关键词

thrombin generation assays,viii,sensitive measurement

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