Agaritine derived from Agaricus blazei Murrill induces apoptosis via mitochondrial membrane depolarization in hematological tumor cell lines.

Atsushi Ogasawara,Hiroki Doi,Taei Matsui,Etsuko Tokunaga, Masao Amakawa,Hidehiko Akiyama

Fujita medical journal（2023）

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摘要

These results indicate that AGT induces apoptosis in K562 and HL60 cells, like U937 reported previously, but showed no effect on THP-1 cells. It was suggested that AGT-induced apoptosis involves the expression of Bax and cytochrome c via mitochondrial membrane depolarization.

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关键词

agaritine,apoptosis,agaricus blazei murrill,hematological tumor cell lines,tumor cell

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