Effect of vinpocetine alone and in combination with enalapril in experimental model of diabetic cardiomyopathy in rats: possible involvement of PDE-1/TGF-β/ Smad 2/3 signalling pathways.

Vishal Kumar Vishwakarma,Sadia Shah,Tajpreet Kaur,Amrit Pal Singh,Sudheer Kumar Arava,Niraj Kumar,Raj Kanwar Yadav,Sushma Yadav,Taruna Arora,Harlokesh Narayan Yadav

The Journal of pharmacy and pharmacology（2023）

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摘要

Vinpocetine is a well-known inhibitor of PDE-1 and the protective effect of vinpocetine in DC is exerted by inhibition of PDE-1 and subsequent inhibition of the expression of TGF-β/Smad 2/3.

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关键词

TGF-β,diabetic cardiomyopathy,oxidative stress,phosphodiesterase-1,vinpocetine

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