Interleukin-11 disrupts alveolar epithelial progenitor function.

Rosa K Kortekaas,Kerstin E Geillinger-Kästle,Theo Borghuis,Kaoutar Belharch,Megan Webster,Wim Timens,Janette K Burgess,Reinoud Gosens

ERJ open research（2023）

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摘要

IL-11 disrupts alveolar epithelial regeneration by inhibiting progenitor activation and suppressing the formation of mature alveolar epithelial cells. Evidence for a contribution of dysregulated fibroblast-epithelial communication to this process is limited.

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关键词

alveolar epithelial progenitor function

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