Multiomics Analyses of Peripheral Artery Disease Muscle Biopsies.

HomeCirculation ResearchVol. 132, No. 11Multiomics Analyses of Peripheral Artery Disease Muscle Biopsies No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextMultiomics Analyses of Peripheral Artery Disease Muscle Biopsies Ishita Jain, Beu P. Oropeza and Ngan F. Huang Ishita JainIshita Jain Department of Cardiothoracic Surgery (I.J., B.P.O., N.F.H.), Stanford University, CA. Stanford Cardiovascular Institute (I.J., B.P.O., N.F.H.), Stanford University, CA. Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System (I.J., B.P.O., N.F.H.). *I. Jain and B.P. Oropeza contributed equally. Search for more papers by this author , Beu P. OropezaBeu P. Oropeza Department of Cardiothoracic Surgery (I.J., B.P.O., N.F.H.), Stanford University, CA. Stanford Cardiovascular Institute (I.J., B.P.O., N.F.H.), Stanford University, CA. Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System (I.J., B.P.O., N.F.H.). *I. Jain and B.P. Oropeza contributed equally. Search for more papers by this author and Ngan F. HuangNgan F. Huang Correspondence to: Ngan F. Huang, PhD, Department of Cardiothoracic Surgery, Stanford University, 300 Pasteur Dr, MC 5407, Stanford, CA 94305. Email E-mail Address: [email protected] https://orcid.org/0000-0003-2298-6790 Department of Cardiothoracic Surgery (I.J., B.P.O., N.F.H.), Stanford University, CA. Stanford Cardiovascular Institute (I.J., B.P.O., N.F.H.), Stanford University, CA. Department of Chemical Engineering (N.F.H.), Stanford University, CA. Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System (I.J., B.P.O., N.F.H.). Search for more papers by this author Originally published25 May 2023https://doi.org/10.1161/CIRCRESAHA.123.322913Circulation Research. 2023;132:1444–1446This article is a commentary on the followingTranscriptomic and Proteomic of Gastrocnemius Muscle in Peripheral Artery DiseaseFootnotes*I. Jain and B.P. Oropeza contributed equally.For Sources of Funding and Disclosures, see page 1446.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Ngan F. Huang, PhD, Department of Cardiothoracic Surgery, Stanford University, 300 Pasteur Dr, MC 5407, Stanford, CA 94305. Email [email protected]eduReferences1. Aday AW, Matsushita K. Epidemiology of peripheral artery disease and polyvascular disease.Circ Res. 2021; 128:1818–1832. doi: 10.1161/CIRCRESAHA.121.318535LinkGoogle Scholar2. Fowkes FGR, Aboyans V, Fowkes FJI, McDermott MM, Sampson UKA, Criqui MH. 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Gene expression signature in patients with symptomatic peripheral artery disease.Arterioscler Thromb Vasc Biol. 2021; 41:1521–1533. doi: 10.1161/ATVBAHA.120.315857LinkGoogle Scholar10. Cong G, Cui X, Ferrari R, Pipinos II, Casale GP, Chattopadhyay A, Sachdev U. Fibrosis distinguishes critical limb ischemia patients from claudicants in a transcriptomic and histologic analysis.J Clin Med. 2020; 9:3974. doi: 10.3390/jcm9123974CrossrefMedlineGoogle Scholar11. Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, et al. Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.JCI Insight. 2018; 3:e123235. doi: 10.1172/JCI.INSIGHT.123235CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. 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Circulation Research. 2023;132:1428-1443 May 26, 2023Vol 132, Issue 11 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.322913PMID: 37228238 Originally publishedMay 25, 2023 Keywordsproteomicsperipheral arterial diseasegene expression profilingchronic limb-threatening ischemiaEditorialPDF download Advertisement