Evaluating metformin strategies for cancer prevention: a target trial emulation using electronic health records.

Barbra A Dickerman,Xabier García-Albéniz,Roger W Logan,Spiros Denaxas,Miguel A Hernán

Epidemiology (Cambridge, Mass.)（2023）

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摘要

Our findings are consistent with the hypothesis that metformin therapy does not meaningfully influence cancer incidence. The findings highlight the importance of explicitly emulating a target trial to reduce bias in the effect estimates derived from observational analyses.

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关键词

Cancer prevention, Causal inference, Comparative effectiveness, Electronic health records, Intention-to-treat analysis, Inverse-probability weighting, Per-protocol analysis, Pharmacoepidemiology, Target trial

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