Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties-Synthesis and biological activity

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie(2023)

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摘要
2-Azabicycloalkanes: 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[3.2.1]octane were used as a chiral platform for the construction of a set of 1,2,3-triazole, thiourea, and ebselen derivatives. Cytotoxicity and antiviral activity studies revealed the most promising potency for selected thioureas.
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关键词
Antiviral activity,2-azabicycloalkane,Cytotoxicity,Ebselen,Thiourea,1,2,3-triazole
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