Transcriptomic changes in liver transplant recipients with non-alcoholic steatohepatitis indicate dysregulation of wound healing.
Frontiers in endocrinology(2023)
Abstract
Beyond altered lipid metabolism, dysregulation of wound healing and tissue repair mechanisms may contribute to the accelerated development of fibrosis associated with PT-NASH. This presents an attractive therapeutic avenue to explore for PT-NASH to optimize the benefit and survival of the graft.
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Key words
liver transplantation, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, disease pathogenesis, fibrosis, wound healing, transcriptomics (RNA-seq), computational biology & bioinformatics
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