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IL-6 Levels Correlate with Prognosis and Immunosuppressive Stromal Cells in Patients with Colorectal Cancer.

Tsunenori Yamamoto,Ryouichi Tsunedomi,Masao Nakajima,Nobuaki Suzuki,Shin Yoshida,Shinobu Tomochika,Ming Xu,Yuki Nakagami,Hiroto Matsui,Yukio Tokumitsu,Yoshitaro Shindo,Yusaku Watanabe,Michihisa Iida,Shigeru Takeda,Shoichi Hazama,Tsuyoshi Tanabe,Tatsuya Ioka,Yoshinobu Hoshii,Akifumi Kiyota,Hitoshi Takizawa,Yutaka Kawakami,Tomio Ueno,Hiroaki Nagano

Annals of surgical oncology（2023）

Cited 2|Views17
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Abstract
Elevated serum IL-6 levels were associated with stromal IL-6 levels in CRC. High IL-6 expression in tumor-infiltrating immune cells also was associated with accumulation of immunosuppressive cells in the TME.
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Key words
Colorectal cancer, Cytokines, Interleukin-6, Lymphocytes, Tumor-infiltrating cells, Tumor microenvironment
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