Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium.
Journal of periodontal research（2023）
Abstract
High glucose-induced impairment of intercellular adhesion molecule expression in gingival epithelial cells was related to the intercellular permeability of gingival cells, representing a possible link to hyperglycemia-related AGE signaling, oxidative stress, and ERK1/2 activation.
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Key words
barrier function, gingival epithelium, hyperglycemia, intercellular adhesion molecules, permeability
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