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Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia.

Anil Kumar,Adeleh Taghi Khani,Caroline Duault,Soraya Aramburo,Ashly Sanchez Ortiz,Sung June Lee, Anthony Chan,Tinisha McDonald,Min Huang,Norman J Lacayo,Kathleen M Sakamoto,Jianhua Yu,Christian Hurtz,Martin Carroll,Sarah K Tasian,Lucy Ghoda,Guido Marcucci,Zhaohui Gu,Steven T Rosen,Saro Armenian,Shai Izraeli,Chun-Wei Chen,Michael A Caligiuri,Stephen J Forman,Holden T Maecker,Srividya Swaminathan

Journal for immunotherapy of cancer（2023）

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Abstract
We find that restoration of the intrinsically suppressed IFN-I production in B-ALL underlies the therapeutic efficacy of IL-15-producing NK cells and that such NK cells represent an attractive therapeutic solution for the problem of drugging MYC in high-grade B-ALL.
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Key words
natural killer cells,interferon production,lymphoblastic leukemia,b-cell
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