Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15

Fei He,Haowen Jiang,Chang Peng,Tingting Wang,Rongrong Xiao,Meilin Chen,Nixue Song,Zhenyun Du,Hanlin Wang,Xiaoyu Ding,Yikai Shao,Jianping Fang,Yi Zang,Rong Hua,Jia Li,Kan Ding

Journal of Hepatology（2023）

引用 0|浏览3

暂无评分

摘要

•Hepatic Glce is attenuated in both obese individuals and HFD-induced obese mice.•Hepatic Glce deficiency accelerates the progression of obesity which is abated by GDF15 treatment.•Glce protects against obesity by facilitating mature GDF15 production and maintaining its ubiquitin homeostasis.•Glce could serve as a novel potential target for obesity treatment.

查看译文

关键词

Glucuronyl C5-epimerase,Growth differentiation factor-15,Obesity,Energy expenditure,Ubiquitination

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要