Mexican perspective on the Mosaico HIV vaccine trial.

Disappointment among researchers and the community is inevitable following the decision to interrupt the Mosaico phase 3 HIV vaccine trial 1 HVTNPhase 3 Mosaic-based investigational HIV vaccine study discontinued following disappointing results of planned data review. https://www.hvtn.org/news/news-releases/2023/01/phase-3-mosaic-based-investigational-hiv-vaccine-study-discontinued-following-disappointing-results-planned-data-review.htmlDate: 2023 Date accessed: January 25, 2023 Google Scholar on the basis of the preplanned data and safety monitoring board analysis in January, 2023. After more than four decades of efforts to develop a vaccine to protect against HIV, Mosaico was the eighth clinical trial to reach an advanced stage in vaccine development (phase 2b/3). Failure to show efficacy is very frustrating after many years of sustained and committed work. 2 Flynn NM Forthal DN Harro CD Judson FN Mayer KH Para MF Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis. 2005; 191: 654-665 Crossref PubMed Scopus (781) Google Scholar , 3 Pitisuttithum P Gilbert P Gurwith M et al. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis. 2006; 194: 1661-1671 Crossref PubMed Scopus (682) Google Scholar , 4 Buchbinder SP Mehrotra DV Duerr A et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008; 372: 1881-1893 Summary Full Text Full Text PDF PubMed Scopus (1413) Google Scholar , 5 Hammer SM Sobieszczyk ME Janes H et al. Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. N Engl J Med. 2013; 369: 2083-2092 Crossref PubMed Scopus (457) Google Scholar , 6 Gray GE Bekker L-G Laher F et al. Vaccine efficacy of ALVAC-HIV and bivalent subtype C gp120-MF59 in adults. N Engl J Med. 2021; 384: 1089-1100 Crossref PubMed Scopus (96) Google Scholar