Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma.

Ryan C Murphy,Ying Lai,Matthew Liu,Taha Al-Shaikhly,Matthew C Altman,William A Altemeier,Charles W Frevert,Jason S Debley,Adrian M Piliponsky,Steven F Ziegler,Sina A Gharib,Teal S Hallstrand

American journal of respiratory and critical care medicine（2023）

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摘要

Circuits involving epithelial interactions with MCs and EOS are closely associated with indirect AHR. Ex vivo modeling indicates that epithelial-dependent regulation of these innate cells may be critical in indirect AHR and modulating T2 and non-T2 inflammation in asthma.

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关键词

airway hyperresponsiveness,asthma,epithelial-innate

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