Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis.

Tingyan Liu,Caiyan Zhang,Jiayun Ying,Yaodong Wang,Gangfeng Yan,Yufeng Zhou,Guoping Lu

Frontiers in immunology（2023）

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摘要

We found a previously uncharacterized role of Notch1 in mediating vascular permeability during sepsis, and we showed that inhibition of NICD resulted in vascular EC dysfunction in sepsis, which was reversed by melatonin. Thus, the Notch1 signaling pathway is a potential target for the treatment of sepsis.

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关键词

sepsis,vascular endothelial intracellular dysfunction,notch1,intracellular domain

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