Long-lived Photoacid-doped Conducting Composites Induce Photocurrent for Efficient Wound Healing.

Electrical stimulation is an effective strategy for facilitating wound healing. However, it is hindered by unwieldy electrical systems. In this study, we used a light-powered dressing based on long-lived photoacid generator (PAG)-doped polyaniline composites, which can generate a photocurrent under visible light irradiation to interact with the endogenous electric field and facilitate skin growth. Light-controlled proton binding and dissociation result in oxidation and reduction of the polyaniline backbone, inducing charge transfer to generate a photocurrent. Due to the rapid intramolecular photoreaction of PAG, a long-lived proton-induced localized acidic environment is formed, which protects the wound from microbial infection. In summary, we have introduced a simple and effective therapeutic strategy for light-powered and biocompatible wound dressings that show great potential for wound treatment. This article is protected by copyright. All rights reserved.