Design, synthesis and anti-hypoxia activity of HPN derivatives containing lipophilic long chains.

Qingyue DA,Jie Zhang,Pengpeng Zhang,Zhiqun Shi,Huiping Ma,Linlin Jing

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences（2022）

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摘要

The synthesis of derivatives 1-5 is convenient, and the yield is high. The synthesized derivatives especially derivative 5 show anti-hypoxic activity similar to or better than HPN at lower doses.

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