Inkiln is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation Via Scaffolding Mkl1 and Usp10

Wei Zhang,Nestor Ishimwe,Jessica Pauli,Clint L. Miller,Neal L. Weintraub,Lars Maegdefessel,Joseph M. Miano,Andrew H. Baker,Xiaochun Long

Circulation（2023）

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摘要

These findings elucidate an important pathway of VSMC inflammation involving an /MKL1/USP10 regulatory axis. Human bacterial artificial chromosome transgenic mice offer a novel and physiologically relevant approach for investigating human-specific long noncoding RNAs under vascular disease conditions.

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关键词

Vascular disease,Inflammation and inflammatory markers,Cell signaling

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