BQ788 Reveals Glial ETB R Modulation of Neuronal Cholinergic and Nitrergic Pathways to Inhibit Intestinal Motility: ETB R Signaling is Linked to POI.

E Mazzotta, I Grants, E Villalobos-Hernandez,S Chaudhuri, J L McClain, L Seguella, D M Kendig, B A Blakeney, K S Murthy,Reiner Schneider,Patrick Leven,Sven Wehner, A Harzman, J R Grider, B D Gulbransen, F L Christofi

British journal of pharmacology（2023）

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摘要

Enteric glial ET-1/ETB signaling provides dual modulation of neural-motor circuits to inhibit motility - It inhibits excitatory cholinergic neural-motor pathways and stimulates inhibitory nitrergic motor pathways. Amplification of glial ETB is linked to muscularis externa inflammation and possibly pathogenic mechanisms of postoperative ileus.

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