Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis.

Koen Venken,Matthias Jarlborg,Tine Decruy,Céline Mortier,Carolien Vlieghe,Elisabeth Gilis,Ann-Sophie De Craemer,Julie Coudenys,Isabelle Cambré, Devan Fleury,Alexander Klimowicz,Filip Van den Bosch,Anne Hoorens,Triana Lobaton,Sytze de Roock,Tim Sparwasser,Gerald Nabozny,Peggy Jacques,Dirk Elewaut

Annals of the rheumatic diseases（2023）

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摘要

These data point to profound differences in immune-regulation between Crohn's ileitis and peripheral arthritis. Whereas Tregs control ileitis they fail to dampen joint inflammation. Synovial resident Tregs are particularly maladapted to chronic TNF exposure.

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关键词

spondyloarthritis, T-lymphocyte subsets, arthritis, experimental

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