The prevalent new-user design for studies with no active comparator: The example of statins and cancer.

Using the prevalent new-user design to emulate a randomized trial when comparing to "non-use" led to results comparable with the more complex successive monthly cohorts approach. The prevalent new-user design emulates the trial in a potentially more intuitive and palpable manner, providing simpler data presentations in line with those portrayed in a classical trial, while producing comparable results.