Adaptive Clinical Trials in Pediatric Critical Care: A Systematic Review.

Patricia Gilholm,Endrias Ergetu,Ben Gelbart,Sainath Raman,Marino Festa,Luregn J Schlapbach,Debbie Long,Kristen S Gibbons

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies（2023）

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摘要

Little evidence of the use of adaptive designs was found, with only 3% of PICU RCTs incorporating an adaptive design and only two types of adaptations used. Identifying the barriers to adoption of more complex adaptive trial designs is needed.

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