Methotrexate plus electroacupuncture reduces autophagy in ankle synovial tissue in rats with rheumatoid arthritis.
American journal of translational research（2023）
Abstract
By inhibiting autophagosome formation, both methotrexate and electroacupuncture inhibit synovial cell autophagy, alleviate synovial cell hyperautophagy, and relieve abnormal synovial hyperplasia, thus exerting a protective effect on the joint synovium. The combination of treatment with methotrexate and electroacupuncture works best.
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Key words
Methotrexate, electroacupuncture, rheumatoid arthritis rats, ankle synovial tissue, autophagy
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