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Effects of Ketamine on Chronic Postsurgical Pain in Patients Undergoing Surgery: A Systematic Review and Meta-analysis.

Wanchen Sun, Yang Zhou, Juan Wang,Yuxuan Fu,Jingyi Fan,Yidan Cui, Yishuang Wu,Lianjie Wang, Yun Yu,Ruquan Han

Pain physician（2023）

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Abstract
We discovered that intravenous ketamine may reduce the incidence of CPSP in patients undergoing surgery, especially 3 - 6 months postsurgery. Because of the small sample size and high heterogeneity of the included studies, the effect of ketamine in the treatment of CPSP still needs to be explored in future large-sample, standardized-assessment studies.
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Key words
Ketamine, chronic postsurgical pain, perioperative period, meta-analysis, randomized controlled trial
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