Integrative single-cell and bulk transcriptomes analyses identify intrinsic HNSCC subtypes with distinct prognoses and therapeutic vulnerabilities.

Yibin Dai,Ziyu Wang, Yingcao Xia,Jin Li,Yaping Wu,Yanling Wang,Hongbing Jiang,Jie Cheng

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

These findings reiterate molecular heterogeneity of HNSCC and advantages of scRNA-seq in pinpointing cellular diversities in complex cancer ecosystems. Our HNSCC iCMS regime might facilitate patient stratification and precision medicine.

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bulk transcriptomes analyses,intrinsic hnscc subtypes,distinct prognoses,single-cell

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