Construction of chiral N , O -hemiaminals via a copper-catalyzed enantioselective Michael/ N -hemiacetalization cascade reaction.
Organic & biomolecular chemistry(2023)
摘要
An efficient Michael/-hemiacetalization cascade reaction of 5-aminoisoxazoles with β,γ-unsaturated α-ketoesters was developed under the catalysis of a chiral copper complex. A series of optically pure six-membered ring ,-hemiaminals were obtained with excellent yields (up to 96% yield) and high enantioselectivities (up to 98% ee). The possible transition state was supported by DFT calculations and thereby the corresponding mechanism was proposed.
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关键词
o-hemiaminals,copper-catalyzed,n-hemiacetalization
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