Plasma and CSF concentrations of N-terminal tau fragments associate with in vivo neurofibrillary tangle burden.
Alzheimer's & dementia : the journal of the Alzheimer's Association(2023)
摘要
An assay for detecting N-terminal tau fragments (NTA-tau) in plasma and CSF was evaluated. NTA-tau is more closely associated with tau PET than amyloid PET or neurodegeneration. NTA-tau can successfully track in vivo tau deposition across the AD continuum. Plasma NTA-tau increased over time only in cognitively impaired amyloid-β positive individuals.
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关键词
vivo neurofibrillary tangle burden,tau,csf concentrations
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