FMISO-PET and immunohistochemistry verified tumor oxygenation, stemness, and immunosupportive microenvironment after preoperative neoadjuvant bevacizumab for newly diagnosed glioblastoma.

Tomoya Suzuki,Jun Takei,Nei Fukasawa,Kenta Suzuki,Daisuke Ogawa,Yohei Yamamoto,Yasuharu Akasaki,Yuichi Murayama,Masayuki Shimoda,Keisuke Miyake,Toshihide Tanaka

World neurosurgery（2023）

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摘要

FMISO-PET effectively visualized TME oxygenation after neo-Bev. Increased FMISO accumulation at the time of recurrence, even under Bev treatment, suggests that FMISO-PET might be useful for monitoring the duration of Bev efficacy by reflecting tumor oxygenation.

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