Synthesis of nucleoside oligophosphates by electrophilic activation of phosphorothioate.
Organic & biomolecular chemistry(2023)
摘要
We herein report a new synthetic method for nucleoside oligophosphates based on electrophilic activation of 5'-phosphorothioate nucleotides. The treatment of phosphorothioate with 2,4-dinitrochlorobenzene (DNCB) efficiently afforded the key activated species, electrophilic thioester nucleotides (EPT-Ns), which were coupled with various phosphate reagents to afford the target nucleoside oligophosphates, including an mRNA cap analog.
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关键词
nucleoside oligophosphates,phosphorothioate,electrophilic activation
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