Posttranslational modifications of the DUX4 protein impact toxic function.

Renatta N Knox,Jocelyn O Eidahl,Lindsay Wallace,Sarah Choudury,Afrooz Rashnonejad,Katelyn Daman, Matthew Guggenbiller,Nizar Saad,Michael E Hoover,Liwen Zhang,Owen E Branson,Charles P Emerson,Michael A Freitas,Scott Q Harper

Annals of neurology（2023）

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摘要

These results support that DUX4 is regulated by PTMs and set a foundation for developing FSHD drug screens based mechanistically on DUX4 PTMs and modifying enzymes. This article is protected by copyright. All rights reserved.

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