Antiretroviral Therapy Intensification for Neurocognitive Impairment in HIV.

Scott L Letendre, Huichao Chen, Ashley McKhann, Jhoanna Roa,Alyssa Vecchio,Eric S Daar,Baiba Berzins,Peter W Hunt,Christina M Marra,Thomas B Campbell,Robert W Coombs,Qing Ma,Shobha Swaminathan,Bernard J C Macatangay,Gene D Morse, Thomas Miller, David Rusin, Alexander L Greninger, Belinda Ha,Beverly Alston-Smith,Kevin Robertson,Robert Paul,Serena Spudich

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

This is the largest, randomized, placebo-controlled trial of ART intensification for NCI in PWH. The findings do not support empiric ART intensification as a treatment for NCI in PWH on suppressive ART. They also do not support that DTG adversely affects cognition, mood, or weight.

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