Extracellular Tau Oligomers Damage the Axon Initial Segment.

Merci N Best, Yunu Lim,Nina N Ferenc, Nayoung Kim, Lia Min,Dora Bigler Wang,Kamyar Sharifi, Anna E Wasserman,Sloane A McTavish,Karsten H Siller, Marieke K Jones,Paul M Jenkins,James W Mandell,George S Bloom

Journal of Alzheimer's disease : JAD（2023）

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摘要

xcTauOs cause partial AIS damage in cultured neurons by a mechanism dependent on intracellular tau, thereby raising the possibility that the observed AIS reduction in AD neurons in vivo is caused by xcTauOs working in concert with endogenous neuronal tau.

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axon initial segment

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