Fecal and serum metabolomic signatures and gut microbiota characteristics of allergic rhinitis mice model.

Zhen Chen, Shancai He,Yihan Wei,Yang Liu,Qingqing Xu,Xing Lin,Chenyu Chen,Wei Lin,Yingge Wang,Li Li,Yuanteng Xu

Frontiers in cellular and infection microbiology（2023）

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Abstract

Our study reveals that AR alters fecal and serum metabolomic signatures and gut microbiota characteristics, and there is a striking correlation between the three. The correlation analysis of the microbiome and metabolome provides a deeper understanding of AR's pathogenesis, which may provide a theoretical basis for AR's potential prevention and treatment strategies.

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Key words

allergic rhinitis, gut microbiota, metabolomics, 16s rDNA sequencing, metabolite, alpha-linoleic acid, Ruminococcus

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