High-throughput Sequencing to Identify Bacteremia in Children with Cancer.

Son H McLaren,Nischay Mishra,Nobuko Hijiya,James Ng,Cheng Guo,Susan Whittier, Erica Mariani, Laura Glaser, Irene Frantzis, Marc T Vindas,Cheng-Shiun Leu,Peter S Dayan

The Pediatric infectious disease journal(2023)

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Abstract
Current methods to diagnose bacteremia are limited. In this pilot study of children with cancer presenting with fever, we determined the concordance between a novel high-throughput sequencing platform called BacCapSeq and blood culture. High-throughput sequencing had modest concordance with blood culture. Discordant organisms included those with both unlikely or potential clinical relevance.
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Key words
high-throughput sequencing,bacteremia,cancer
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