Glucocorticoids are differentially synthesized along the murine and human respiratory tree.

Verena M Merk,Pietro Renzulli,Bart Vrugt,Achim Fleischmann,Thomas Brunner

Allergy（2023）

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摘要

We report here the differential synthesis of bioactive GC along the murine and human respiratory tree. Thus, extra-adrenal de novo GC synthesis and reactivation may differentially contribute to the regulation of immunological and inflammatory processes in the lung.

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关键词

Cyp11b1, extra-adrenal, glucocorticoids, Hsd11b1, lung

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