Genotype-Phenotype Models Predicting VO2max Response to High-Intensity Interval Training in Physically Inactive Chinese.

The PPS, baseline VO2max, sex and body mass could explain the variance in VO2max response. Individuals who had a PPS greater than 1.757 had the highest training response after 12 weeks of HIIT. Genetic variants in a region on chromosome 6, especially the sterile alpha motif domain containing 5 gene (SAMD5) which had been explored influencing angiogenesis, might have a potential role in the VO2max response.