Implementation of CYP2C19 genotyping to guide proton pump inhibitor use at an academic health center.

Emily J Cicali,Cameron D Thomas,Amanda Elchynski,Benish Alam,Rachel Dalton, Rick Davis,Eda Eken,David Estores,Khoa Nguyen,Larisa H Cavallari,Kristin Wiisanen

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists（2023）

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摘要

Guiding PPI prescribing based on CYP2C19 genotype is a practical approach to potentially improve the benefit-risk ratio with PPI therapy. Physician engagement is key for successful implementation. A CPIC guideline on CYP2C19 genotype-guided PPI dosing is now available, and automated alerts may be instituted to facilitate implementation.

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关键词

proton pump inhibitor use,proton pump inhibitor

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