R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.

Munehisa Shimamura,Hiroki Hayashi,Nan Ju,Shota Yoshida,Satoshi Baba,Tsutomu Sasaki,Hideki Mochizuki,Ryuichi Morishita,Hironori Nakagami

Stroke（2023）

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摘要

RSPO3/LGR4 signaling plays a critical role in regulating TLR-induced inflammation and neurite outgrowth in the ischemic brain. Enhancing this signal will be a promising approach for treating ischemic stroke.

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关键词

neurite outgrowth signaling system,novel inflammatory,ischemic brain,3/lgr4,receptor,r-spondin,leucine-rich,repeat-containing,protein-coupled

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