SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice.

J Love,Sergio Rodriguez-Aponte,Lisa Tostanoski,Neil Dalvie,Ryan Johnston,Catherine Jacob-Dolan,Olivia Powers,Nicole Hachmann,Jessica Miller,Kevin Hall,Mazuba Siamatu,Camille Mazurek,Nehalee Surve,Dan Barouch

Research square（2023）

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摘要

We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer induced neutralizing activity similar to the RBD-VLP. A RBD hetero-dimer and RBD-VLP also shows comparable breadth to other SARS-CoV-2 variants-of-concern (VOCs).

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关键词

vlps,mice,sars-cov

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