Serum metabolomic adaptations following a 12-week High-Intensity Interval Training combined to citrulline supplementation in obese older adults.

Layale Youssef,Sylvère Durand,Fanny Aprahamian,Deborah Lefevre,Melanie Bourgin,Maria Chiara Maiuri,Maude Dulac,Guy Hajj-Boutros,Vincent Marcangeli,Fanny Buckinx,Eva Peyrusqué,José A Morais,Pierrette Gaudreau,Gilles Gouspillou,Guido Kroemer,Mylène Aubertin-Leheudre,Philippe Noirez

European journal of sport science（2023）

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Abstract

A 12-week intervention involving high-intensity interval training (HIIT) with or without citrulline (CIT) supplementation induced adaptations in the serum metabolome of obese older adults through significant changes in 44 metabolites.Changes in 23 metabolites were observed when a CIT supplementation was administered along with a 12-week HIIT intervention.TG (16:1/18:1/16:0) correlated with several adiposity parameters including leptin, triglycerides, legs lean mass.Aspartic acid correlated with several adiposity parameters including leptin, LDL cholesterol as well as android, arms and trunk fat mass.

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Key words

metabolomic adaptations,supplementation,obese older adults,training,high-intensity

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