Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients. Alex S Genshaft , Sonu Subudhi , Arlin Keo , Juan Diego Sanchez Vasquez , Nádia Conceição-Neto , Deeqa Mahamed , Lauke L Boeijen , Nadia Alatrakchi , Chris Oetheimer , Mike Vilme , Riley Drake , Ira Fleming , Nancy Tran , Constantine Tzouanas , Jasmin Joseph-Chazan , Martin Arreola Villanueva , Harmen J G van de Werken , Gertine W van Oord , Zwier M A Groothuismink , Boris J Beudeker , Zgjim Osmani , Shirin Nkongolo , Aman Mehrotra , Kurt Spittaels , Jordan Feld , Raymond T Chung , Robert J de Knegt , Harry L A Janssen , Jeroen Aerssens , Jacques Bollekens , Nir Hacohen , Georg M Lauer , Andre Boonstra , Alex K Shalek , Adam J Gehring Hepatology (Baltimore, Md.)（2023）
摘要
The ability to electively sample and intensively profile the immune landscape of the liver, and generate high-resolution data, will enable multi-site clinical studies to identify biomarkers for intrahepatic immune activity in HBV and beyond.
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