Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.

Antoine Leuzy,Alexa Pichet Binette,Jacob W Vogel,Gregory Klein,Edilio Borroni,Matteo Tonietto,Olof Strandberg,Niklas Mattsson-Carlgren,Sebastian Palmqvist,Michael J Pontecorvo,Leonardo Iaccarino,Erik Stomrud,Rik Ossenkoppele,Ruben Smith,Oskar Hansson

JAMA neurology（2023）

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摘要

Finding suggest that certain individualized ROIs carry an advantage over group-level ROIs for assessing longitudinal tau changes and increase the power to detect treatment effects in AD clinical trials using longitudinal tau PET as an outcome.

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关键词

alzheimer disease,individualized brain regions,tomography,group-level

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