HER2 chimeric antigen receptor T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma.

Stacie S Wang,Alexander J Davenport,Melinda Iliopoulos,Hannah E Hughes-Parry,Katherine A Watson,Valeria Arcucci,Matthias Mulazzani,David D Eisenstat,Jordan R Hansford,Ryan S Cross,Misty R Jenkins

Neuro-oncology advances（2023）

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摘要

HER2 CAR T cells are already in clinic development and are well tolerated in pediatric patients. Here we provide strong preclinical evidence for the inclusion of DIPG patients in future pediatric CNS tumor HER2 CAR T cell clinical trials.

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关键词

Chimeric antigen receptor (CAR) T cells, diffuse intrinsic pontine glioma (DIPG), diffuse midline glioma (DMG), human epidermal growth factor receptor 2 (HER2), immunotherapy

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