Hydroxychloroquine sulfate: A novel treatment for lipin-1 deficiency?

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie（2023）

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摘要

HCQ improves the condition of patients with lipin-1 deficiency, but at low concentrations. In vitro, 1 µM HCQ decreases oxidative stress in myoblasts whereas higher concentrations have a deleterious effect by blocking autophagy.

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关键词

LPIN1, Hydroxychloroquine, Autophagy, Oxidative stress, Treatment

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