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Induction of endoplasmic reticulum stress is associated with the anti-tumor activity of monepantel across cancer types.

Tiffany J Harris,Yang Liao, Wei Shi,Marco Evangelista,Bhupinder Pal,Hamsa Puthalakath, Roger Aston,Richard Mollard,John M Mariadason,Erinna F Lee,Walter D Fairlie

Cancer medicine（2023）

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Abstract
As these outcomes are all associated with mTOR signalling, cell cycle and autophagy, we now provide a likely triggering mechanism for the anti-cancer activity of monepantel.
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Key words
endoplasmic reticulum stress,cancer,monepantel
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